Descripción de la oferta
About the team/job We are looking for a postdoc to join our groups at EMBL Barcelona. In particular, Haase and Dayton labs, have expertise in 3D vascularized models and human alveolar and airway organoids, respectively. The project aim is to develop patient-specific healthy and disease (chronic obstructive pulmonary disease, COPD) lung tissue models. In collaboration with Cellzome (GSK), the project will focus on vascularization strategies for precision cut lung slices (an established technique), as vascularization may improve the longevity and phenotype of the lung tissue as a model for drug discovery and testing. In parallel, we aim to use the donor lung tissue to develop patient-matched vascular models (as those currently developed in Haase lab) as well as airway and alveolar organoids (as those in Dayton lab). We aim to leverage these models to recapitulate and dissect mechanisms of lung disease including COPD, and potentially fibrosis. Ultimately, this project will focus on drug responses across all 3 patient-specific in vitro model systems. This position is based in Barcelona, but will require occasional travel to the Heidelberg site. The posting is for 2 years but may be renewable. Your role The successful candidate will learn, in collaboration with Cellzome and Pepperkok lab (EMBL Heidelberg), to prepare, culture and characterize hPCLS from donor lung tissue. The candidate will
