Descripción de la oferta
We are looking for a highly motivated candidate willing to pursue a PhD in our young and dynamic ChemSynBio team at IQS School of Engineering - Ramon Llull University in Barcelona!
Group
At ChemSynBio (www.chemsynbio.iqs.edu), we harness chemical and synthetic biology to create biotherapeutic and biomedical tools, especially to treat brain diseases and to understand brain transport. We aim to conduct groundbreaking research and to grow together!
Project
Extracellular targeted protein degradation has emerged as a new therapeutic modality. Several drugs exploiting this strategy are already in clinical trials and many exciting avenues remain to be explored in this new thriving field. In this project, we aim to develop a new platform to generate smart protein degraders with superior selectivity and degradation efficiency for the treatment of brain tumors. This project is highly interdisciplinary, involving directed evolution, protein engineering, bioconjugation, and proteomics, as well as cell-based assays and efficacy tests in mice. The candidate will be involved in all stages of the project, focusing on protein development and cellular experiments. This position is part of the State Plan for Scientific and Technological Research and Innovation of the Ministry for Science and Technology of the Spanish Government.
Tasks
Contribution to research excellence at all stages: literature review, experimental design, experimentation, data analysis, and proposal of new research directions.
Collaboration with other researchers and contribution to an inspiring atmosphere.
Presentation of results and contribution to preparing reports and scientific publications.
Engagement in laboratory management and team activities.
Training in technical and horizontal skills. Student supervision and training.
Conditions
Three years of funding guaranteed with a possible extension.
Training opportunities, close supervision, and space for creativity.
Expenses derived from research stays, PhD tuition fees.
Proposed starting date (flexible): September 2026.
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