Descripción de la oferta
OverviewPre-announcement, pending the official call announcement. The Nanostructured Films and Particles Group (NFP) at INMA is looking for a Research Technician to join the ERC Starting Grant project SEVEN - Screening metastasis targeting properties of extracellular vesicle’s biomolecular corona for Engineering therapeutic biomimetic nanoparticles.PROJECT DESCRIPTIONMetastasis research is one of the greatest challenges in the medical field. The nanoengineering of inorganic/organic nanoparticles (NPs) with natural signaling carriers such as extracellular vesicles (EVs) is a promising tool to address the lack of treatment efficiency of currently available therapies, blamed on the insufficient accumulation of the antitumoral molecules in the metastasis tissues. Despite several years of intense efforts, therapeutic EVs are still far away from clinical practice. Recent studies have evidenced that this failure is due to the lack of knowledge on how EVs behave in biological environments and how their therapeutic cargo affects the metastasis targeting moieties present on their membranes. Seven believes that the lack of attention on the unknown biomolecular corona (BC) and on its role governing the EVs’ biological identity may well be behind such uncertainties. Understanding EVs’ BC formation will improve the rational EV-inspired nano-therapy design. SEVEN has been designed to generate substantial understating of the NPs- loaded therapeutic EVs behavior, the BC identity and its surface topography to generate new vectors with a much improved accumulation in metastasis target tissues. SEVEN will validate BC’s influence in the EVs metastasis targeting properties in a conceptually and operational ground-breaking experimental design to modify the BC’s surfactome composition for tailoring their therapeutic action. In addition, SEVEN will use supercritical fluid technology as a new scalable and reproducible strategy to create high yield loading of therapeutic NPs-loaded EVs-inspired therapies, maintaining their natural metastasis signaling properties and overcoming the main limitations that have prevented their successful translation to the clinic. All this will allow SEVEN to screen most promising metastasis targeting tailored EVs (loaded with therapeutic NPs) in patient-derived orthotropic xenograft (PDOXs) models.ResponsibilitiesTechnical tasks related with:Cell culture experimentsPreparation of samples for in vitro experimentsNanomaterials characterizationProtocols design and developmentQuality and security controlResearch supportMaintenance of equipment and instrumentsHost research groupNFP (https://nfp.unizar.es/) is a multidisciplinary group composed by researchers from very diverse backgrounds (chemists, biochemists, biotechnologists and engineers), with the aim of carrying out cutting-edge research in the areas of nanomaterials design and applications. In the field of nanomedicine, the group develops nanomaterials whose special properties provide advantages in medical applications compared to conventional therapies. Specifically, we work on the design of new therapeutic vectors based on nanomaterials that are capable of penetrating biological barriers, delivering their cargo selectively and acting locally. The group has made important contributions, including pioneering developments that have opened new opportunities. It is notably funded through national and European projects, including several ERC Grants, and has established significant collaborations with leading groups in this field.Position detailsJob status: full-timeLocation: Zaragoza, SpainQualifications: Bachelor Chemistry/Biotechnology or similarHow to applySubmit your expression of interest to María Sancho Albero (msancho@unizar.es) together with a motivation letter.Official call opening expected during March 2026.
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