Descripción de la oferta
University: French Alternative Energies and Atomic Energy Commission (CEA)Country: FranceDeadline: 2026-09-23Fields: Microbiology, Molecular Biology, Biochemistry, Bioinformatics, Clinical Research
About The University Or Research Institute
The French Alternative Energies and Atomic Energy Commission (CEA) is a world‑renowned public research institution headquartered in France, recognized for its leadership in technological innovation and scientific excellence. CEA spans multiple campuses and is at the forefront of research in energy, defense, health and environmental sciences. Its fundamental research division plays a pivotal role in advancing human health and personalized medicine, fostering a collaborative academic environment that bridges basic science and translational applications.
Research Topic and Significance
This PhD position is embedded within the Marie Skłodowska‑Curie Doctoral Network METAMIC 3, an ambitious European Commission‑funded project aimed at advancing microbiome science through metaproteomics. The specific focus will be on the "Long‑term dynamics of the CF microbiota during CFTR modulator therapy." Recent advances in CFTR modulators have revolutionised treatment for cystic fibrosis (CF) but the long‑term effects on the airway microbiome remain poorly understood. Your research will integrate functional microbiome profiles with clinical data to map changes in the airway microbiota over time, identify key effectors mediating pathogen‑commensal interactions, and uncover biomarkers or therapeutic targets to better manage airway infections and improve quality of life for CF patients.
Project Details
As a doctoral candidate you will join the Li2D laboratory at CEA Marcoule, working within the ProGénoMix group that develops advanced mass spectrometry‑based approaches for microbiome characterization and pathogen detection. The project is part of the larger METAMIC 3 network, bringing together leading experts from academia, industry and the public sector to address One Health challenges through interdisciplinary research and training. You will participate in two international secondments: three months in Professor P. Wilmes’ lab in Luxembourg for functional annotation of proteins, and four months at the Centre de Ressource et de Compétence de la Mucoviscidose in France for hands‑on CF clinical research and sampling. Throughout your PhD you will independently plan and execute experiments, maintain rigorous documentation, analyse complex data and present findings at international conferences and peer‑reviewed journals.
Candidate Profile
The ideal candidate is a motivated and ambitious researcher with a strong background in biology, biochemistry, molecular medicine or a closely related field. You should have a master’s, diploma or equivalent degree obtained before the contract start date, experience in protein biochemistry, microbiome research or molecular biology, and a strong interest in clinical microbiome research and translational science. Excellent teamwork skills, the ability to thrive in an interdisciplinary international environment, proficiency in scientific English, and willingness to spend several months abroad as part of the project’s secondments are essential.
Requirements
Must not already possess a doctoral degree (PhD).
Must not have resided or carried out your main activity in France for more than 12 months in the 3 years immediately prior to recruitment (as per Marie Skłodowska‑Curie mobility rules).
A master’s, diploma or equivalent degree in biology, biochemistry, molecular medicine or a similar field.
Experience in protein biochemistry, microbiome research or molecular biology.
Strong interest in clinical microbiome research and translational science.
Excellent teamwork skills and ability to work in an interdisciplinary, international setting.
Proficiency in scientific English (written and spoken).
Willingness to spend several months abroad at partner institutions as part of the project’s secondments.
Application Process
The closing date for applications is 23/09/2026. The anticipated start date is 01/04/2026. Applications should be submitted quoting "DC05" in the subject header. Candidates should prepare the following documents:
An extended curriculum vitae with a full publication list.
A cover letter.
Copies of diplomas.
A two-page research statement clearly describing your research profile, interests in the position, and methodological expertise.
Names and contact information of two references, if available.
Conclusion
This PhD position at the French Alternative Energies and Atomic Energy Commission (CEA) offers a unique opportunity to engage in high‑impact microbiome research within an internationally recognized training network. If you are eager to advance your scientific career in a supportive, interdisciplinary environment and make a real difference in human health, we encourage you to apply for this exciting opportunity.
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